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- Title
Effect of radiation on the penetration of irinotecan in rat cerebrospinal fluid.
- Authors
Khatri, Amit; Gaber, M Waleed; Brundage, Richard C; Naimark, Michael D; Hanna, Suzan K; Stewart, Clinton F; Kirstein, Mark N
- Abstract
Anticancer agents are useful for treating brain tumors, but sub therapeutic concentrations due to decreased blood-brain barrier (BBB) penetration limit their effectiveness. This study evaluated the effect of cranial radiation on the pharmacokinetics of irinotecan in plasma and cerebrospinal fluid (CSF).
- Publication
Cancer chemotherapy and pharmacology, 2011, Vol 68, Issue 3, p721
- ISSN
1432-0843
- Publication type
Journal Article
- DOI
10.1007/s00280-010-1542-3