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- Title
Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats.
- Authors
Kapetanovic, Izet M; Muzzio, Miguel; Huang, Zhihua; Thompson, Thomas N; McCormick, David L
- Abstract
Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a naturally occurring polyphenol with a broad range of possible health benefits, including anti-cancer activity. However, the biological activity of resveratrol may be limited by poor absorption and first-pass metabolism: only low plasma concentrations of resveratrol are seen following oral administration, and metabolism to glucuronide and sulfate conjugates is rapid. Methylated polyphenol analogs (such as pterostilbene [3,5-dimethoxy-4'-hydroxy-trans-stilbene], the dimethylether analog of resveratrol) may overcome these limitations to pharmacologic efficacy. The present study was designed to compare the bioavailability, pharmacokinetics, and metabolism of resveratrol and pterostilbene following equimolar oral dosing in rats.
- Publication
Cancer chemotherapy and pharmacology, 2011, Vol 68, Issue 3, p593
- ISSN
1432-0843
- Publication type
Journal Article
- DOI
10.1007/s00280-010-1525-4