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- Title
Modulatory effects of curcumin on multi-drug resistance-associated protein 5 in pancreatic cancer cells.
- Authors
Li, Yan; Revalde, Jezrael L; Reid, Glen; Paxton, James W
- Abstract
Chemotherapy of pancreatic cancer often fails due to the development of intrinsic and acquired resistance during drug treatment. Recent studies have suggested that MRP5 conferred resistance to first-line drugs 5-fluorouracil and gemcitabine by active efflux of drugs from the cell. Our aim was to evaluate whether curcumin could reverse this multi-drug resistance by inhibition of MRP5-mediated efflux.
- Publication
Cancer chemotherapy and pharmacology, 2011, Vol 68, Issue 3, p603
- ISSN
1432-0843
- Publication type
Journal Article
- DOI
10.1007/s00280-010-1515-6