We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Conjugation of chlorin p(6) to histamine enhances its cellular uptake and phototoxicity in oral cancer cells.
- Authors
Parihar, Arpana; Dube, Alok; Gupta, P K
- Abstract
Our previous studies in hamster cheek pouch model have shown that chlorin p (6) (Cp (6)), a chlorophyll derivative is a suitable photosensitizer for photodynamic treatment (PDT) of small tumors (<5 mm). However, for bigger tumors, the accumulation of Cp (6) was inadequate, which compromised the effectiveness of PDT. The purpose of present study was to investigate the possibility of improving the cellular uptake of Cp (6) by conjugating it to histamine, a biogenic amine that is known to modulate tumor growth and development via cell surface receptors.
- Publication
Cancer chemotherapy and pharmacology, 2011, Vol 68, Issue 2, p359
- ISSN
1432-0843
- Publication type
Journal Article
- DOI
10.1007/s00280-010-1492-9