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- Title
Plasma and CNS pharmacokinetics of O4-benzylfolic acid (O4BF) and metabolite in a non-human primate model.
- Authors
Chuk, Meredith K; Cole, Diane E; McCully, Cynthia; Loktionova, Natalia A; Pegg, Anthony E; Parker, Robert J; Pauly, Gary; Widemann, Brigitte C; Balis, Frank M; Fox, Elizabeth
- Abstract
O(6)-alkylguanine-DNA alkyltransferase (AGT) repairs DNA damage from alkylating agents by transferring the alkyl adducts from the O(6)-position of guanine in DNA to AGT. The folate analog O(4)-benzylfolic acid (O(4)BF) is an inhibitor of AGT with reported selectivity of the alpha-folate receptor in tumors. We studied plasma and cerebrospinal fluid (CSF) pharmacokinetics and CSF penetration of O(4)BF in a non-human primate model.
- Publication
Cancer chemotherapy and pharmacology, 2011, Vol 67, Issue 6, p1291
- ISSN
1432-0843
- Publication type
Journal Article
- DOI
10.1007/s00280-010-1407-9