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- Title
SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo.
- Authors
Arbitrario, Jennifer P; Belmont, Brian J; Evanchik, Marc J; Flanagan, W Michael; Fucini, Raymond V; Hansen, Stig K; Harris, Shannon O; Hashash, Ahmad; Hoch, Ute; Hogan, Jennifer N; Howlett, Anthony R; Jacobs, Jeffrey W; Lam, Joni W; Ritchie, Sean C; Romanowski, Michael J; Silverman, Jeffrey A; Stockett, David E; Teague, Juli N; Zimmerman, Kristin M; Taverna, Pietro
- Abstract
The Aurora family of serine/threonine kinases (Aurora-A, Aurora-B, and Aurora-C) plays a key role in cells orderly progression through mitosis. Elevated expression levels of Aurora kinases have been detected in a high percentage of melanoma, colon, breast, ovarian, gastric, and pancreatic tumors. We characterized the biological and pharmacological properties of SNS-314, an ATP-competitive, selective, and potent inhibitor of Aurora kinases.
- Publication
Cancer chemotherapy and pharmacology, 2010, Vol 65, Issue 4, p707
- ISSN
1432-0843
- Publication type
Journal Article
- DOI
10.1007/s00280-009-1076-8