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- Title
Bone marrow CFU-GM and human tumor xenograft efficacy of three tubulin binding agents.
- Authors
Kurtzberg, Leslie S; Roth, Stephanie D; Bagley, Rebecca G; Rouleau, Cecile; Yao, Min; Crawford, Jennifer L; Krumbholz, Roy D; Schmid, Steven M; Teicher, Beverly A
- Abstract
The dynamic instability of microtubules in cells is one of the key targets of anticancer therapeutics. Microtubule-disrupting agents such as vinca alkaloids and microtubule-stabilizing agents such as taxanes are important antitumor agents. The bone marrow toxicity and human tumor xenograft activity of three tubulin-binding compounds, vincristine, paclitaxel, and tasidotin were compared.
- Publication
Cancer chemotherapy and pharmacology, 2009, Vol 64, Issue 5, p1029
- ISSN
1432-0843
- Publication type
Journal Article
- DOI
10.1007/s00280-009-0959-z