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Title
Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro.
Authors
Jeong, Seongwook; Woo, Margaret M; Flockhart, David A; Desta, Zeruesenay
Abstract
To determine the inhibitory potency of letrozole and its main human metabolite, 4,4'-methanol-bisbenzonitrile, on the activities of eight cytochrome P450 (CYP) enzymes.
Publication
Cancer chemotherapy and pharmacology, 2009, Vol 64, Issue 5, p867