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- Title
Lack of toxicity of a STAT3 decoy oligonucleotide.
- Authors
Sen, Malabika; Tosca, Patricia J; Zwayer, Christa; Ryan, Michael J; Johnson, Jerry D; Knostman, Katherine A B; Giclas, Patricia C; Peggins, James O; Tomaszewski, Joseph E; McMurray, Timothy P; Li, Changyou; Leibowitz, Michael S; Ferris, Robert L; Gooding, William E; Thomas, Sufi M; Johnson, Daniel E; Grandis, Jennifer R
- Abstract
STAT3 overexpression has been detected in several cancers including head and neck squamous cell carcinoma (HNSCC). Previous studies using intratumoral administration of a STAT3 decoy oligonucleotide that abrogates STAT3-mediated gene transcription in preclinical cancer models have demonstrated antitumor efficacy. This study was conducted to observe the toxicity and biologic effects of the STAT3 decoy in a non-human primate model, in anticipation of initiating a clinical trial in HNSCC patients.
- Publication
Cancer chemotherapy and pharmacology, 2009, Vol 63, Issue 6, p983
- ISSN
1432-0843
- Publication type
Journal Article
- DOI
10.1007/s00280-008-0823-6