We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo.
- Authors
O'Reilly, Terence; Wartmann, Markus; Brueggen, Joseph; Allegrini, Peter R; Floersheimer, Andreas; Maira, Michel; McSheehy, Paul M J
- Abstract
Patupilone is a microtubule stabilizer (MTS) currently in clinical development. Here, we evaluate the anti-cancer activity in vitro and in vivo in comparison to paclitaxel and describe the pharmacokinetics (PK) of patupilone in tumor-bearing nude mice and rats.
- Publication
Cancer chemotherapy and pharmacology, 2008, Vol 62, Issue 6, p1045
- ISSN
1432-0843
- Publication type
Journal Article
- DOI
10.1007/s00280-008-0695-9