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- Title
2-Methoxyestradiol reverses doxorubicin resistance in human breast tumor xenograft.
- Authors
Azab, Samar S; Salama, Salama A; Hassan, Memy H; Khalifa, Amani E; El-Demerdash, Ebtehal; Fouad, Hala; Al-Hendy, Ayman; Abdel-Naim, Ashraf B
- Abstract
2-Methoxyestradiol (2ME), an endogenous estradiol metabolite, was developed as a novel agent based on its antitumor activity and lack of toxicity. This study was designed to investigate the modulatory effect of 2ME on the antitumor effect of doxorubicin (Dox) in resistant breast tumor xenograft. Resistant MCF-7/Dox cells were implanted subcutaneously in nude mice
- Publication
Cancer chemotherapy and pharmacology, 2008, Vol 62, Issue 5, p893
- ISSN
0344-5704
- Publication type
Journal Article
- DOI
10.1007/s00280-008-0679-9