We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Oxaliplatin-induced immune mediated thrombocytopenia.
- Authors
Beg, Muhammad S; Komrokji, Rami S; Ahmed, Kashif; Safa, Malek M
- Abstract
Oxaliplatin is a third generation platinum compound used in patients with advanced colorectal carcinoma. Recently, the mechanism of a rare drug-induced immune thrombocytopenia in patients receiving oxaliplatin has been described. This complication is caused by oxaliplatin-dependent antibodies directed against platelet surface glycoproteins, and is unrelated to myelosuppression. In this report, we describe two patients who developed thrombocytopenia immediately soon after receiving oxaliplatin. Sensitization presumably had occurred after receiving oxaliplatin during preceding courses of multiagent chemotherapy that included oxaliplatin.
- Publication
Cancer chemotherapy and pharmacology, 2008, Vol 62, Issue 5, p925
- ISSN
0344-5704
- Publication type
Journal Article
- DOI
10.1007/s00280-007-0675-5