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- Title
RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide.
- Authors
Moreb, Jan S; Mohuczy, Dagmara; Ostmark, Blanca; Zucali, James R
- Abstract
Aldehyde dehydrogenases class-1A1 (ALDH1A1) and class-3A1 (ALDH3A1) have been associated with resistance to cyclophosphamide (CP) and its derivatives. We have previously reported the downregulation of these enzymes by all-trans retinoic acid (ATRA).
- Publication
Cancer chemotherapy and pharmacology, 2007, Vol 59, Issue 1, p127
- ISSN
0344-5704
- Publication type
Journal Article
- DOI
10.1007/s00280-006-0233-6