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- Title
The anti-tumour effect of low-dose continuous chemotherapy may partly be mediated by thrombospondin.
- Authors
Damber, Jan-Erik; Vallbo, Christina; Albertsson, Per; Lennernäs, Bo; Norrby, Klas
- Abstract
Tumour growth is dependent on angiogenesis. Antiangiogenic chemotherapy, i.e. continuous or metronomic low-dose chemotherapy, is a method for administrating cytostatics at a low and well-tolerated concentration without prolonged breaks. The target is the genetically stable endothelial cells playing a pivotal role in angiogenesis within the tumour. Different mediators could mediate the antiangiogenic effect of metronomic chemotherapy. One of these mediators could be thrombospondin (TSP). TSP is a potent inhibitor of angiogenesis and might therefore be important in controlling tumour growth. This study was designed to evaluate the effects of low-dose continuous or moderate-dose bolus chemotherapy on tumour growth and on tumour expression of TSP.
- Publication
Cancer chemotherapy and pharmacology, 2006, Vol 58, Issue 3, p354
- ISSN
0344-5704
- Publication type
Journal Article
- DOI
10.1007/s00280-005-0163-8