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- Title
Assessment of normal and tumor tissue uptake of MAG-CPT, a polymer-bound prodrug of camptothecin, in patients undergoing elective surgery for colorectal carcinoma.
- Authors
Sarapa, Nenad; Britto, Margaret R; Speed, William; Jannuzzo, MariaGabriella; Breda, Massimo; James, Christopher A; Porro, MariaGrazia; Rocchetti, Maurizio; Wanders, Alkvin; Mahteme, Haile; Nygren, Peter
- Abstract
MAG-camptothecin (MAG-CPT) is the lead compound of a novel drug delivery system in which an active cytotoxic moiety, camptothecin (CPT), is covalently linked to a soluble polymeric carrier (MAG) to form an inactive prodrug. The mechanism of action of CPT remains unaltered, but the delivery system is thought to allow the carrier-bound drug to accumulate in tumor tissues and release the active CPT locally. This proof-of-concept clinical study was designed to determine whether MAG-CPT was preferentially delivered to or retained in tumor tissue compared to adjacent normal tissue or plasma, and to estimate the degree of intratissue release of CPT.
- Publication
Cancer chemotherapy and pharmacology, 2003, Vol 52, Issue 5, p424
- ISSN
0344-5704
- Publication type
Journal Article
- DOI
10.1007/s00280-003-0685-x