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- Title
Phase I and pharmacokinetic study of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) using a single intravenous dose schedule.
- Authors
Feun, Lynn; Modiano, Manuel; Lee, King; Mao, John; Marini, Angela; Savaraj, Niramol; Plezia, Patricia; Almassian, Bijan; Colacino, Elizabeth; Fischer, Jessica; MacDonald, Susan
- Abstract
To perform a phase I and pharmacokinetics study of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) a new ribonucleotide reductase inhibitor using a single intravenous (2-h) schedule every 4 weeks. 3-AP was given at a starting dose of 5 mg/m(2) with escalation based on a modified Fibonacci scheme.
- Publication
Cancer chemotherapy and pharmacology, 2002, Vol 50, Issue 3, p223
- ISSN
0344-5704
- Publication type
Journal Article
- DOI
10.1007/s00280-002-0480-0