We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Enhanced antitumor activities of TZT-1027 against TNF-alpha or IL-6 secreting Lewis lung carcinoma in vivo.
- Authors
Natsume, Tsugitaka; Koh, Yasuhiro; Kobayashi, Motohiro; Fukumoto, Hisao; Takahashi, Fumiyuki; Nakamura, Takashi; Ohe, Yuichiro; Saijo, Nagahiro; Nishio, Kazuto
- Abstract
TZT-1027, an antimicrotubule agent that inhibits the polymerization of tubulin, shows potent antitumor activity in various transplantable tumor models in vivo. The high antitumor activity of TZT-1027 prompted us to speculate that this compound may have a mode of action other than its antimicrotubule and antimitotic activities. To elucidate the interaction of antitumor cytokines with TZT-1027 in tumors in vivo, we examined the antitumor activity of this agent against various cytokine gene-transfected Lewis lung carcinoma (LLC) cells inoculated into C57BL/6 mice.
- Publication
Cancer chemotherapy and pharmacology, 2002, Vol 49, Issue 1, p35
- ISSN
0344-5704
- Publication type
Journal Article
- DOI
10.1007/s00280-001-0388-0