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- Title
Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats.
- Authors
Egorin, Merrill J; Lagattuta, Theodore F; Hamburger, Deborah R; Covey, Joseph M; White, Kevin D; Musser, Steven M; Eiseman, Julie L
- Abstract
17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin (17DMAG) is an analogue of the benzoquinone ansamycin compound 17-(allylamino)-17-demethoxygeldanamycin (17AAG), which is currently being evaluated in clinical trials. Studies were performed in mice and rats to: (1) define the plasma pharmacokinetics, tissue distribution, and urinary excretion of 17DMAG after i.v. delivery; (2) define the bioavailability of 17DMAG after i.p. and oral delivery; (3) characterize the biliary excretion of 17DMAG after i.v. delivery to rats; and (4) characterize, if possible, any metabolites of 17DMAG observed in plasma, tissue, urine, or bile.
- Publication
Cancer chemotherapy and pharmacology, 2002, Vol 49, Issue 1, p7
- ISSN
0344-5704
- Publication type
Journal Article
- DOI
10.1007/s00280-001-0380-8