Successful treatment of advanced peripheral T-cell lymphoma with an angiocentric growth pattern complicated with hemophagocytic syndrome by high-dose chemotherapy and autologous peripheral blood stem cell transplantation.

Sato, T.; Kogawa, K.; Iyama, S.; Kobayashi, D.; Sato, Y.; Kuribayashi, K.; Takada, K.; Hagiwara, S.; Oku, T.; Takahashi, S.; Matsunaga, T.; Takahashi, M.; Terui, T.; Kato, J.; Niitsu, Y.

Peripheral T-cell lymphomas (PTCL) account for about 10% of all lymphomas in Western countries, respond poorly to therapy, and have short survival with no sustained remission. Furthermore, the complication of hemophagocytic syndrome (HPS) sometimes makes the prognosis of this disease extremely worse. We report here a case of PTCL with an angiocentric growth pattern complicated with HPS successfully treated by high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Our case suggests this approach is an excellent candidate for the treatment of this disease.

LYMPHOMAS; T cells; PHAGOCYTES; STEM cell transplantation; SYNDROMES; DRUG therapy

Annals of Hematology, 2002, Vol 81, Issue 12, p739

0939-5555

Academic Journal

10.1007/s00277-002-0561-5