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- Title
Somatostatin, Somatostatin Receptors, and Pancreatic Cancer.
- Authors
Min Li; Fisher, William E.; Hee Joon Kim; Xiaoping Wang; Brunicardi, Charles F.; Changyi Chen; Qizhi Yao
- Abstract
Somatostatin may play an important role in the regulation of cancer growth including pancreatic cancer by interaction with somatostatin receptors (SSTRs) on the cell surface. Five SSTRs were cloned, and the function of these SSTRs is addressed in this review. SSTR-2, SSTR-5, and SSTR-1 are thought to play major roles in inhibiting pancreatic cancer growth both in vitro and in vivo. SSTR-3 may be involved in mediating apoptosis, but the role of SSTR-4 is not clear. In most pancreatic cancers, functional SSTRs are absent. Reintroduction of SSTR genes has been shown to inhibit pancreatic cancer growth in cell cultures and animal models.
- Publication
World Journal of Surgery, 2005, Vol 29, Issue 3, p293
- ISSN
0364-2313
- Publication type
Academic Journal
- DOI
10.1007/s00268-004-7814-5