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- Title
Humoral anti-KLH responses in cancer patients treated with dendritic cell-based immunotherapy are dictated by different vaccination parameters.
- Authors
Aarntzen, Erik H J G; de Vries, I Jolanda M; Göertz, Joop H; Beldhuis-Valkis, Marjo; Brouwers, Huberdina M L M; van de Rakt, Mandy W M M; van der Molen, Renate G; Punt, Cornelis J A; Adema, Gosse J; Tacken, Paul J; Joosten, Irma; Jacobs, Joannes F M
- Abstract
Keyhole limpet hemocyanin (KLH) attracts biomedical interest because of its remarkable immunostimulatory properties. Currently, KLH is used as vaccine adjuvant, carrier protein for haptens and as local treatment for bladder cancer. Since a quantitative human anti-KLH assay is lacking, it has not been possible to monitor the dynamics of KLH-specific antibody (Ab) responses after in vivo KLH exposure. We designed a quantitative assay to measure KLH-specific Abs in humans and retrospectively studied the relation between vaccination parameters and the vaccine-induced anti-KLH Ab responses.
- Publication
Cancer immunology, immunotherapy : CII, 2012, Vol 61, Issue 11, p2003
- ISSN
1432-0851
- Publication type
Journal Article
- DOI
10.1007/s00262-012-1263-z