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- Title
WT1 peptide vaccinations induce CD4 and CD8 T cell immune responses in patients with mesothelioma and non-small cell lung cancer.
- Authors
Krug, Lee M; Dao, Tao; Brown, Andrew B; Maslak, Peter; Travis, William; Bekele, Sara; Korontsvit, Tatyana; Zakhaleva, Victoria; Wolchok, Jedd; Yuan, Jianda; Li, Hao; Tyson, Leslie; Scheinberg, David A
- Abstract
The transcription factor, WT1, is highly overexpressed in malignant pleural mesothelioma (MPM) and immunohistochemical stains for WT1 are used routinely to aid in its diagnosis. Using computer prediction analysis we designed analog peptides derived from WT1 sequences by substituting amino acids at key HLA-A0201 binding positions. We tested the safety and immunogenicity of a WT1 vaccine comprised of four class I and class II peptides in patients with thoracic neoplasms expressing WT1.
- Publication
Cancer immunology, immunotherapy : CII, 2010, Vol 59, Issue 10, p1467
- ISSN
1432-0851
- Publication type
Journal Article
- DOI
10.1007/s00262-010-0871-8