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- Title
Two-compartment model of radioimmunotherapy delivered through cerebrospinal fluid.
- Authors
He, Ping; Kramer, Kim; Smith-Jones, Peter; Zanzonico, Pat; Humm, John; Larson, Steven M; Cheung, Nai-Kong V
- Abstract
Radioimmunotherapy (RIT) using (131)I-3F8 injected into cerebrospinal fluid (CSF) was a safe modality for the treatment of leptomeningeal metastases (JCO, 25:5465, 2007). A single-compartment pharmacokinetic model described previously (JNM 50:1324, 2009) showed good fitting to the CSF radioactivity data obtained from patients. We now describe a two-compartment model to account for the ventricular reservoir of (131)I-3F8 and to identify limiting factors that may impact therapeutic ratio.
- Publication
European journal of nuclear medicine and molecular imaging, 2011, Vol 38, Issue 2, p334
- ISSN
1619-7089
- Publication type
Journal Article
- DOI
10.1007/s00259-010-1633-8