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- Title
Development of a potent DOTA-conjugated bombesin antagonist for targeting GRPr-positive tumours.
- Authors
Mansi, Rosalba; Wang, Xuejuan; Forrer, Flavio; Waser, Beatrice; Cescato, Renzo; Graham, Keith; Borkowski, Sandra; Reubi, Jean Claude; Maecke, Helmut R
- Abstract
Radiolabelled somatostatin-based antagonists show a higher uptake in tumour-bearing mouse models than agonists of similar or even distinctly higher receptor affinity. Very similar results were obtained with another family of G protein-coupled receptor ligands, the bombesin family. We describe a new conjugate, RM2, with the chelator DOTA coupled to D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH(2) via the cationic spacer 4-amino-1-carboxymethyl-piperidine for labelling with radiometals such as (111)In and (68)Ga.
- Publication
European journal of nuclear medicine and molecular imaging, 2011, Vol 38, Issue 1, p97
- ISSN
1619-7089
- Publication type
Journal Article
- DOI
10.1007/s00259-010-1596-9