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- Title
An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors.
- Authors
Lepin, Eric J; Leyton, Jeffrey V; Zhou, Yu; Olafsen, Tove; Salazar, Felix B; McCabe, Katelyn E; Hahm, Scott; Marks, James D; Reiter, Robert E; Wu, Anna M
- Abstract
Prostate stem cell antigen (PSCA), a cell surface glycoprotein expressed in normal human prostate and bladder, is over-expressed in the majority of localized prostate cancer and most bone metastases. We have previously shown that the hu1G8 minibody, a humanized anti-PSCA antibody fragment (single-chain Fv-C(H)3 dimer, 80 kDa), can localize specifically and image PSCA-expressing xenografts at 21 h post-injection. However, the humanization and antibody fragment reformatting decreased its apparent affinity. Here, we sought to evaluate PET imaging contrast with affinity matured minibodies.
- Publication
European journal of nuclear medicine and molecular imaging, 2010, Vol 37, Issue 8, p1529
- ISSN
1619-7089
- Publication type
Journal Article
- DOI
10.1007/s00259-010-1433-1