We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A standardised study to compare prostate cancer targeting efficacy of five radiolabelled bombesin analogues.
- Authors
Schroeder, Rogier P J; Müller, Cristina; Reneman, Suzanne; Melis, Marleen L; Breeman, Wout A P; de Blois, Erik; Bangma, Chris H; Krenning, Eric P; van Weerden, Wytske M; de Jong, Marion
- Abstract
Prostate-specific antigen (PSA)-based screening for prostate cancer (PC) has dramatically increased early diagnosis. Current imaging techniques are not optimal to stage early PC adequately. A promising alternative to PC imaging is peptide-based scintigraphy using radiolabelled bombesin (BN) analogues that bind to gastrin-releasing peptide receptors (GRPR) being overexpressed in PC. When labelled to appropriate radionuclides BN targeting of GRPRs may also provide applications for peptide radionuclide receptor therapy (PRRT). Assessment studies under identical experimental conditions allowing a reliable comparison of the potential of such analogues are lacking. This study was performed to evaluate and directly compare five promising radiolabelled BN analogues for their targeting efficacy for PC under standardised conditions.
- Publication
European journal of nuclear medicine and molecular imaging, 2010, Vol 37, Issue 7, p1386
- ISSN
1619-7089
- Publication type
Journal Article
- DOI
10.1007/s00259-010-1388-2