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- Title
Detection of amyloid in Alzheimer’s disease with positron emission tomography using [<sup>11</sup>C]AZD2184.
- Authors
Nyberg, Svante; Jönhagen, Maria; Cselényi, Zsolt; Halldin, Christer; Julin, Per; Olsson, Hans; Freund-Levi, Yvonne; Andersson, Jan; Varnäs, Katarina; Svensson, Samuel; Farde, Lars
- Abstract
Current positron emission tomography (PET) radioligands for detection of Aβ amyloid in Alzheimer’s disease (AD) are not ideal for quantification. To improve the signal to noise ratio we have developed the radioligand [11C]AZD2184 and report here the first clinical evaluation. Eight AD patients and four younger control subjects underwent 93-min PET measurements with [11C]AZD2184. A ratio approach using the cerebellum as reference region was applied to determine binding parameters. Brain uptake of [11C]AZD2184 peaked within 1 min at 3–4% of injected radioactivity. AD patients had high radioactivity in cortical regions while controls had uniformly low radioactivity uptake. Specific binding peaked within 30 min at which time standardized uptake value ratios (SUVR) ranged between 1.19 and 2.57. [11C]AZD2184 is a promising radioligand for detailed mapping of Aβ amyloid depositions in Alzheimer’s disease, due to low non-specific binding, high signal to background ratio and reversible binding as evident from early peak equilibrium.
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2009, Vol 36, Issue 11, p1859
- ISSN
1619-7070
- Publication type
Academic Journal
- DOI
10.1007/s00259-009-1182-1