Title

Naturally occurring aromatic steroids and their biological activities.

Authors

Dembitsky, Valery M.; Savidov, Nick; Poroikov, Vladimir V.; Gloriozova, Tatyana A.; Imbs, Andrew B.

Abstract

The present review describes the distribution and biological activities of natural mono-, di-, and triaromatic steroids. It is shown that the producers of aromatic steroids are microorganisms, fungi, and marine invertebrates, and also they were found in plants, animals, marine sediments, and karst deposits. Eighty biologically active aromatic steroids likely have an anti-tumor, anti-inflammatory, and neuroprotection activity with a confidence of 78 to 92%. The structures and predicted biological activities of aromatic steroids are available. This review emphasizes the role of aromatic steroids as an important source and potential leads for drug discovery and they are of great interest to chemists, physicians, biologists, pharmacologists, and the pharmaceutical industry.

Subjects

STEROIDS analysis; LIPID analysis; NEUROPROTECTIVE agents; MICROORGANISMS; INVERTEBRATES; DRUG development

Publication

Applied Microbiology & Biotechnology, 2018, Vol 102, Issue 11, p4663

ISSN

0175-7598

Publication type

Academic Journal

DOI

10.1007/s00253-018-8968-7