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- Title
Therapeutic insulins and their large-scale manufacture.
- Authors
Walsh, Gary
- Abstract
Biotechnological innovations over the past 25 years have underpinned the rapid development of a thriving biopharmaceutical sector. Therapeutic insulin remains one of the most commonly used products of pharmaceutical biotechnology and insulin-based products command annual global sales in excess of $4.5 billion. Innovations in its method of production and in particular the advent of engineered insulin analogues provide a fascinating insight into how scientific and technological advances have impacted upon the pharmaceutical biotechnology sector as a whole. Current insulin-based diabetes research is increasingly focused not on the insulin molecule per se, but upon areas such as the development of non-parenteral insulin delivery systems, as well as organ-/cell-based and gene therapy-based approaches to controlling the disease.
- Publication
Applied microbiology and biotechnology, 2005, Vol 67, Issue 2, p151
- ISSN
0175-7598
- Publication type
Journal Article
- DOI
10.1007/s00253-004-1809-x