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- Title
Aspergillus niger citric acid accumulation: do we understand this well working black box?
- Authors
Karaffa, Levente; Kubicek, Christian P
- Abstract
This Mini-Review summarizes the current knowledge on the biochemical and physiological events leading to massive citric acid accumulation by Aspergillus niger under industrially comparable conditions, thereby particularly emphasizing the roles of glycolytic flux and its control, excretion of citric acid from the mitochondria and the cytosol, and the critical fermentation variables. The potential of novel techniques for metabolic analysis and genomic approaches in understanding this fermentation is also discussed.
- Publication
Applied microbiology and biotechnology, 2003, Vol 61, Issue 3, p189
- ISSN
0175-7598
- Publication type
Journal Article
- DOI
10.1007/s00253-002-1201-7