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- Title
Evolution, expression and effectiveness in a cluster of novel bovine beta-defensins.
- Authors
Cormican, Paul; Meade, Kieran G; Cahalane, Sarah; Narciandi, Fernando; Chapwanya, Aspinas; Lloyd, Andrew T; O'Farrelly, Cliona
- Abstract
The anti-microbial peptides beta-defensins constitute a large family of innate immune effector molecules, conserved across a wide species range. In this paper, we describe a systematic search of the sequenced bovine genome to characterise this extensive gene family in Bos taurus, providing an insight into the pattern of conservation of beta-defensin genes between species. We have sequenced a sub-set of these newly discovered bovine beta-defensin genes and also report expression data for these genes across a range of tissues. We have synthesised the peptide product of one of these genes, bovine beta-defensin 123, and found it to be a potent inhibitor of several pathogenic microbes, particularly Escherichia coli and Listeria monocytogenes.
- Publication
Immunogenetics, 2008, Vol 60, Issue 3-4, p147
- ISSN
0093-7711
- Publication type
Journal Article
- DOI
10.1007/s00251-007-0269-8