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- Title
The effects of cholesterol and β-sitosterol on the structure of saturated diacylphosphatidylcholine bilayers.
- Authors
Gallová, Jana; Uhríková, Daniela; Kučerka, Norbert; Doktorovová, Slavomíra; Funari, Sérgio S; Teixeira, José; Balgavý, Pavol
- Abstract
The structures of DMPC and DPPC bilayers in unilamellar liposomes, in the presence of 33.3 mol% cholesterol or the plant sterol β-sitosterol, have been studied by small-angle neutron scattering. The bilayer thickness d(L) increases in a similar way for both sterols. The repeat distance in multilamellar liposomes, as determined by small-angle X-ray diffraction, is larger in the presence of β-sitosterol than in the presence of cholesterol. We observe that each sterol modifies the interlamellar water layer differently, cholesterol reducing its thickness more efficiently than β-sitosterol, and conclude that cholesterol suppresses bilayer undulations more effectively than β-sitosterol.
- Publication
European biophysics journal : EBJ, 2011, Vol 40, Issue 2, p153
- ISSN
1432-1017
- Publication type
Journal Article
- DOI
10.1007/s00249-010-0635-6