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- Title
A new concept of olfactory biosensor based on interdigitated microelectrodes and immobilized yeasts expressing the human receptor OR17-40.
- Authors
Marrakchi, Mouna; Vidic, Jasmina; Jaffrezic-Renault, Nicole; Martelet, Claude; Pajot-Augy, Edith
- Abstract
This work shows the feasibility of an olfactory biosensor based on the immobilization of Saccharomyces cerevisiae yeast cells genetically modified to express the human olfactory receptor OR17-40 onto interdigitated microconductometric electrodes. This olfactory biosensor has been applied to the detection of its specific odorant (helional) with a high sensitivity (threshold 10(-14) M). In contrast, no significant response was observed using a non-specific odorant (heptanal), which suggests a good selectivity. Thus, this work may represent a first step towards a new kind of bioelectronic noses based on whole yeast cells and allowing a real time monitoring of olfactory receptor activation.
- Publication
European biophysics journal : EBJ, 2007, Vol 36, Issue 8, p1015
- ISSN
0175-7571
- Publication type
Journal Article
- DOI
10.1007/s00249-007-0187-6