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- Title
Membrane water-penetration profiles from spin labels.
- Authors
Marsh, Derek
- Abstract
Spin label hyperfine splittings in mixtures of protic and aprotic solvents are used to obtain association constants K(A,h) for hydrogen bonding to oxazolidine nitroxides. With the Onsager approach to account for the variation in local dielectric constant, these results are used to determine the effective penetration profile of water into fluid phospholipid membranes, from recent electron paramagnetic resonance (EPR) studies on phospholipids spin-labelled systematically down the sn-2 chain. Water penetration is appreciable, depends on chain unsaturation, and is strongly affected by cholesterol.
- Publication
European biophysics journal : EBJ, 2002, Vol 31, Issue 7, p559
- ISSN
0175-7571
- Publication type
Journal Article
- DOI
10.1007/s00249-002-0245-z