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- Title
Regulation of the expression of the prostate-specific antigen by claudin-7.
- Authors
Zheng, J-Y; Yu, D; Foroohar, M; Ko, E; Chan, J; Kim, N; Chiu, R; Pang, S
- Abstract
Claudins are a family of proteins involved in forming tight junctions between cells. Here we describe two forms of claudin-7 (CLDN-7), a full-length form of CLDN-7 with 211 amino-acid residues and a C-terminal truncated form with 158 amino-acid residues. These two forms of CLDN-7 are able to regulate the expression of a tissue-specific protein, the prostate-specific antigen (PSA), in the LNCaP prostate cancer cell line. We also found that the expression of CLDN-7 is responsive to androgen stimulation in the LNCaP cell line, suggesting that this protein is involved in the regulatory mechanism of androgen. Both forms of claudin-7 are expressed in human prostate, kidney and lung samples, and in most samples, the full-length form of claudin-7 was predominant. However, in some prostate samples from healthy individuals, the truncated form of claudin-7 is predominantly expressed. Our results demonstrated that unlike other claudins, CLDN-7 has both structural and regulatory functions, and the two forms of CLDN-7 may be related to cell differentiation in organ development.
- Publication
The Journal of membrane biology, 2003, Vol 194, Issue 3, p187
- ISSN
0022-2631
- Publication type
Journal Article
- DOI
10.1007/s00232-003-2038-4