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- Title
Prediction of phenprocoumon maintenance dose and phenprocoumon plasma concentration by genetic and non-genetic parameters.
- Authors
Geisen, Christof; Luxembourg, Beate; Watzka, Matthias; Toennes, Stefan W; Sittinger, Katja; Marinova, Milka; von Ahsen, Nicolas; Lindhoff-Last, Edelgard; Seifried, Erhard; Oldenburg, Johannes
- Abstract
The anticoagulation response to vitamin K antagonists is characterised by high inter-individual variability. The impact of single nucleotide polymorphisms (SNPs) in several genes of enzymes involved in the vitamin K cycle on phenprocoumon dose variability and phenprocoumon plasma concentrations is still under investigation.
- Publication
European journal of clinical pharmacology, 2011, Vol 67, Issue 4, p371
- ISSN
1432-1041
- Publication type
Journal Article
- DOI
10.1007/s00228-010-0950-y