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- Title
Effect of ritonavir on the pharmacokinetics of the benzimidazoles albendazole and mebendazole: an interaction study in healthy volunteers.
- Authors
Corti, Natascia; Heck, Antje; Rentsch, Katharina; Zingg, Walter; Jetter, Alexander; Stieger, Bruno; Pauli-Magnus, Christiane
- Abstract
Benzimidazoles are often used concomitantly with protease inhibitors in patients with helminthic disease and HIV infection. Low bioavailability and extensive first-pass metabolism make benzimidazoles prone to pharmacokinetic drug interactions. The aim of the present study was to investigate potential drug interactions between the benzimidazoles albendazole and mebendazole and the potent CYP3A4 inhibitor ritonavir.
- Publication
European journal of clinical pharmacology, 2009, Vol 65, Issue 10, p999
- ISSN
1432-1041
- Publication type
Journal Article
- DOI
10.1007/s00228-009-0683-y