We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors.
- Authors
Johnson, L'aurelle A; Oetting, William S; Basu, Saonli; Prausa, Susie; Matas, Arthur; Jacobson, Pamala A
- Abstract
Mycophenolic acid (MPA) is glucuronidated primarily by uridine diphosphate glucuronosyltransferase enzymes (UGT) 1A9 and 1A8. These enzymes are highly polymorphic resulting in low activity and high expression phenotypes. We hypothesized that polymorphisms of UGT1A9 and 1A8 may alter MPA pharmacokinetics in kidney transplantation.
- Publication
European journal of clinical pharmacology, 2008, Vol 64, Issue 11, p1047
- ISSN
1432-1041
- Publication type
Journal Article
- DOI
10.1007/s00228-008-0501-y