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- Title
Pharmacokinetics and tolerability of artesunate and amodiaquine alone and in combination in healthy volunteers.
- Authors
Orrell, Catherine; Little, Francesca; Smith, Peter; Folb, Peter; Taylor, Walter; Olliaro, Piero; Barnes, Karen I
- Abstract
The WHO recommends artemisinin-based combination therapies for treatment of uncomplicated falciparum malaria. At least 15 African countries have adopted artesunate plus amodiaquine as treatment policy. As no pharmacokinetic data on this combination have been published to date, we investigated its pharmacokinetic interactions and tolerability in healthy volunteers in Africa.
- Publication
European journal of clinical pharmacology, 2008, Vol 64, Issue 7, p683
- ISSN
1432-1041
- Publication type
Journal Article
- DOI
10.1007/s00228-007-0452-8