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- Title
Maintenance of indinavir by dose adjustment in HIV-1-infected patients with indinavir-related toxicity.
- Authors
Wasmuth, J-C; Lambertz, I; Voigt, E; Vogel, M; Hoffmann, C; Burger, D; Rockstroh, J K
- Abstract
Treatment with indinavir/ritonavir (IDV/RTV) is very effective but hampered by frequent development of IDV-associated adverse events (mainly nephrotoxicity and skin changes). We tested whether dose reduction of IDV guided by therapeutic drug monitoring resulted in improved tolerability without compromising antiviral efficacy.
- Publication
European journal of clinical pharmacology, 2007, Vol 63, Issue 10, p901
- ISSN
1432-1041
- Publication type
Journal Article
- DOI
10.1007/s00228-007-0343-z