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- Title
The pharmacokinetics of erythropoietin in the cerebrospinal fluid after intravenous administration of recombinant human erythropoietin.
- Authors
Xenocostas, Anargyros; Cheung, Wing K; Farrell, Francis; Zakszewski, Cindy; Kelley, Marian; Lutynski, Andrzej; Crump, Michael; Lipton, Jeffrey H; Kiss, Thomas L; Lau, Catherine Y; Messner, Hans A
- Abstract
Erythropoietin (EPO) was originally described as a regulator of erythropoiesis. Recently, synthesis of EPO and expression of the EPO receptor (EPO-R) have been reported for the central nervous system (CNS). The potential use of EPO to prevent or reduce CNS injury and the paucity of information regarding its entry into the human CNS led us to examine the pharmacokinetics (PK) of recombinant human EPO (r-HuEPO) in the serum and cerebrospinal fluid (CSF).
- Publication
European journal of clinical pharmacology, 2005, Vol 61, Issue 3, p189
- ISSN
0031-6970
- Publication type
Journal Article
- DOI
10.1007/s00228-005-0896-7