We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy.
- Authors
Holthe, Monica; Klepstad, Pål; Zahlsen, Kolbjørn; Borchgrevink, Petter C; Hagen, Lars; Dale, Ola; Kaasa, Stein; Krokan, Hans E; Skorpen, Frank
- Abstract
UDP-glucuronosyltransferase (UGT) 2B7 is the major UGT isoform responsible for the 3- and 6-glucuronidation of morphine in humans. Studies in rats have indicated that UGT1A1 may also contribute to the formation of morphine 3-glucuronide (M3G). Our objective was to investigate whether the UGT2B7 H268Y and UGT1A1*28 polymorphisms contribute to the variability in morphine glucuronide-to-morphine plasma ratios among cancer patients undergoing analgesic therapy with morphine.
- Publication
European journal of clinical pharmacology, 2002, Vol 58, Issue 5, p353
- ISSN
0031-6970
- Publication type
Journal Article
- DOI
10.1007/s00228-002-0490-1