Enantioselective separation of defined endocrine-disrupting nonylphenol isomers.

Acir, Ismail-Hakki; Wüst, Matthias; Guenther, Klaus

Nonylphenol is in the focus of worldwide endocrine-disrupter research and accounted for as a priority hazardous substance of the Water Framework Directive of the European Union. Technical nonylphenol consists of a very complex mixture of isomers and enantiomers. As estrogenic effect and degradation behavior in environmental processes of single nonylphenols are heavily dependent on the structure of the nonyl side chain, it is absolutely necessary to consider the nonylphenol problem from an isomer and enantiomer-specific viewpoint. In this study, an enantiomer-specific separation of eight defined synthesized nonylphenol isomers by five different special chiral cyclodextrin columns was performed underivatized and after methylation, silylation, and acylation. This work demonstrates that three columns out of the investigated five show an excellent separation behavior for the studied different nonylphenol isomers and can be used for the enantiomer-specific determination of nonylphenols in food, other biological matrices, and environmental samples in the future. [Figure not available: see fulltext.]

NONYLPHENOL; ENANTIOSELECTIVE catalysis; ISOMERS; ENANTIOMERS; METHYLATION; ACYLATION; SILYLATION

Analytical & Bioanalytical Chemistry, 2016, Vol 408, Issue 20, p5601

1618-2642

Academic Journal

10.1007/s00216-016-9661-2