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- Title
Quantifying the 5-HT1A agonist action of buspirone in man.
- Authors
Bridge, M W; Marvin, G; Thompson, C E; Sharma, A; Jones, D A; Kendall, M J
- Abstract
Buspirone is used as a neuroendocrine challenge in which the increase of circulating prolactin is taken as a measure of the sensitivity of central serotonergic (5-HT(1A)) pathways. Interpretation of the test is complicated, however, by the fact that buspirone possesses D(2) antagonist and 5-HT(1A) agonist activity, both of which will result in the release of prolactin. To understand the significance of prolactin secretion in response to buspirone, it is important to measure the differential actions of the two controlling pathways.
- Publication
Psychopharmacology, 2001, Vol 158, Issue 3, p224
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s002130100881