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- Title
The effect of neuroleptic medication on prepulse inhibition in schizophrenia patients: current status and future issues.
- Authors
Hamm, A O; Weike, A I; Schupp, H T
- Abstract
Prepulse inhibition (PPI) of the startle reflex is a powerful tool for investigating sensorimotor gating in both animals and humans. Evidence of impaired PPI in patients with schizophrenia suggests that PPI performance might serve as a promising model to investigate the neurobiological mechanisms of this disorder. Animal data show that experimentally induced PPI deficits can be removed by the administration of antipsychotic agents. Recent clinical studies suggest that neuroleptic medication is capable of improving deficient PPI performance in schizophrenia patients as well.
- Publication
Psychopharmacology, 2001, Vol 156, Issue 2-3, p259
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s002130100827