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- Title
Environmental animal models for sensorimotor gating deficiencies in schizophrenia: a review.
- Authors
Weiss, I C; Feldon, J
- Abstract
In schizophrenia research, the study of animal models has received considerable attention in the past 20 years. The value of animal models in pre-clinical research is widely recognised, largely because they can provide precious knowledge regarding the neurobiology of schizophrenia and can also be used for developing antipsychotic drugs. Prepulse inhibition (PPI; reduction in startle reflex induced by a prestimulus) is impaired in schizophrenic patients, a finding that has been associated with a loss of sensorimotor gating abilities. In rats, the schizophrenic-like PPI deficit can be induced by pharmacological or surgical manipulations targeting mainly the cortico-meso-limbic circuitry.
- Publication
Psychopharmacology, 2001, Vol 156, Issue 2-3, p305
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s002130100800