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Title
Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges.
Authors
Swerdlow, N R; Geyer, M A; Braff, D L
Abstract
Sensorimotor gating of the startle reflex can be assessed across species, using similar stimuli to elicit similar responses. Prepulse inhibition (PPI), a measure of sensorimotor gating, is reduced in patients with some neuropsychiatric disorders, and in rats after manipulations of limbic cortex, striatum, pallidum or pontine tegmentum ("CSPP" circuitry).