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- Title
Isradipine prevents global and regional cocaine-induced changes in brain blood flow: a preliminary study.
- Authors
Johnson, B; Barron, B; Fang, B; Lamki, L; Wagner, L; Wells, L; Kenny, P; Overton, D; Dhother, S; Abramson, D; Chen, R; Kramer, L
- Abstract
The L-type calcium channel antagonist, isradipine, reduces brain ischemia in animal models of ischemic stroke. These effects of isradipine appear more pronounced in dopamine (DA) rich brain regions. These same DA-rich brain regions have also been shown to be the areas most affected by cocaine-induced ischemic changes. Using a novel quantified approach to single photon emission computerized tomography, we demonstrated that isradipine pre-treatment prevented cocaine-induced ischemic changes, especially in these DA-rich brain regions. This is the first demonstration that any medication, including isradipine, can prevent the ischemic effects of cocaine on brain blood flow. Isradipine may, therefore, be a useful therapeutic agent for the prevention of brain ischemia in cocaine addicts.
- Publication
Psychopharmacology, 1998, Vol 136, Issue 4, p335
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s002130050575