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- Title
Transplacental transfer of amitriptyline and nortriptyline in isolated perfused human placenta.
- Authors
Heikkinen, T; Ekblad, U; Laine, K
- Abstract
Although tricyclic antidepressants (TCAs) have gained wide acceptance for use in the treatment of depression in pregnant women, their pharmacokinetics during pregnancy have been poorly characterized. The aim of the present study was to investigate the transplacental transfer of amitriptyline (AMI) and its main active metabolite nortriptyline (NOR) in isolated perfused human placenta.
- Publication
Psychopharmacology, 2001, Vol 153, Issue 4, p450
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s002130000597