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- Title
Modulation of morphine sensitization in the rat by contextual stimuli.
- Authors
Badiani, A; Oates, M M; Robinson, T E
- Abstract
The repeated administration of addictive drugs, such as amphetamine, cocaine, and morphine, produces a progressive enhancement (sensitization) of their psychomotor activating effects. We have previously shown that administration of amphetamine or cocaine in a distinct test environment promotes more robust psychomotor sensitization than if they are given at home. No information is available, however, on whether this environmental manipulation has a similar effect on sensitization to morphine, a drug that enhances dopamine (DA) release in the striatum indirectly by disinhibiting midbrain DA neurons.
- Publication
Psychopharmacology, 2000, Vol 151, Issue 2-3, p273
- ISSN
0033-3158
- Publication type
Journal Article
- DOI
10.1007/s002130000447